Glaucoma is a multifactorial optic neuropathy, influences more than 50 million individuals and is the second driving reason for visual deficiency around the world. The part of intra Ocular Pressure (IOP) has been recorded as a noteworthy modifiable danger variable for glaucoma. Also, numerous glaucoma patients have low IOP, while some solid people have a moderately high IOP. The clutters can be separated into two primary classes, open-angle glaucoma and closed angle glaucoma. Disabled visual blood stream regulation in open angle glaucoma as a danger of glaucoma has been entrenched, particularly in the course of recent decades. Pathophysiology of glaucoma demonstrates towards the expanded in intraocular weight which packs and harms the optic nerve and once the optic nerve is harmed, it neglects to convey visual data and this outcome in loss of vision. The precise pathophysiology of glaucoma adding to this is yet to be resolved. Biomarkers for glaucoma have prescient utilization that could help and direct treatment in some glaucoma patients. Endothelin in glaucoma treatment assume an exceptionally part in pathogenesis of glaucoma. Glaucoma represents more than 10 million visits to doctors every year. Regarding social security advantages, lost wage charge incomes, and medicinal services consumptions, the expense to the U.S. government is assessed to be over $1.5 billion every year. The Glaucoma Research Society of Canada is the main Canadian non-benefit association committed to financing glaucoma research. In 1989, it has raised more than two million dollars in backing of 150 Bascom Palmer and Wills Eye are the top scientist association for glaucoma.